Human colorectal tumors bear recurrent mutations in genes encoding proteins operative in the WNT, MAPK, TGF-β, TP53 and PI3K pathways. Although these pathways influence intestinal stem cell niche signaling, the extent to which mutations in these pathways contribute to human colorectal carcinogenesis . Hereditary hemolytic anemia (HHA) is a group of heterogeneous disorders with diverse genetic etiologies. The clinical presentation ranges from mild hemolytic anemia to severe, transfusion-dependent hemolytic anemia with varied complications. The AlphaLISA ® SureFire ® Ultra ™ Human and Mouse Total SMAD4 assay is a sandwich immunoassay for quantitative detection of total SMAD4 in cellular lysates using Alpha Technology. Price Range: USD - USD New .

Smad Pathway

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ARUP Scientific Resource for Research and Education. This site is hosted by ARUP Laboratories and the University of Utah Department of Pathology as a scientific and educational resource for pathologists and professionals in laboratory medicine. ARUP is an enterprise of the University of Utah and its Department of Pathology. Nov 07,  · SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. APC ARID1A ATM BAP1 BRAF BRCA1 BRCA2 CDKN2A CTNNB1 EGFR ERBB2 FAT1 FBXW7 KRAS MTOR NF1 NOTCH1 NRAS PIK3CA PIK3R1 POLE PTEN RB1 SMAD4 TP mutants Models Click to view. DepMap Programmes at Sanger. The Cell Model Passports is an integral part of the Cancer Dependency Map at Sanger. DepMap | Genes.

tissues with high or low expression of SMAD4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. Gene: SMAD4 ENSG Description. SMAD family member 4 [Source:HGNC Symbol;Acc:HGNC]. Gene Synonyms. DPC4, MADH4. Location. SMAD4 (SMAD family member 4, also known as DPC4), is a gene that encodes the mothers against decapentaplegic homolog 4 protein, one of eight SMAD proteins. Knockout Tested Rabbit recombinant monoclonal Smad4 antibody [EPY]. Validated in WB, IHC and tested in Mouse, Rat, Human. Cited in publication(s). Transforming growth factor-beta (TGF-beta) suppresses tumor formation by blocking cell cycle progression and maintaining tissue homeostasis. In pancreatic carcinomas, this tumor suppressive activity is often lost by inactivation of the TGF-beta-signaling mediator, Smad4. We found that human pancreat . Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Zhang, Q., Xiao, M., Gu, S., Xu, Y., Liu, T., Li, H., Feng, X.-H. (). ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.

Hsap\SMAD4. Species. H. sapiens. Name. SMAD family member 4. Annotation Symbol. Feature Type. engineered_foreign_gene. FlyBase ID. FBgn The SMAD4 gene is associated with autosomal dominant juvenile polyposis syndrome (JPS) (MedGen UID: ), hereditary hemorrhagic telangiectasia (HHT). Alterations in the SMAD4 gene was primarily discovered in pancreatic cancer (duct adenocarcinoma) but occur in a variety of cancers such as colorectal.

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Smad4 - Nov 07,  · SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis.

Smad4 - Zhang, Q., Xiao, M., Gu, S., Xu, Y., Liu, T., Li, H., Feng, X.-H. (). ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.